The Board of Trustees of City of Knowledge is one of its cornerstones, both organizationally and philosophically. Headed by Mr. Juan David Morgan, it is made up of fundamental people from the academic, entrepreneurial, governmental and legislative arenas, who ensure quality contributions to the management and follow-up of the Foundation's goals.
Board of Directors| Name | Organization |
| Mr. Juan David Morgan | |
| Mr. Eldredge Bermingham | Smithsonian Tropical R. |
| Mr. Roberto Roy | |
| Mr. Eloy Alfaro | |
| Mr. Gilberto Guardia | |
| Mr. Fernando Manfredo | |
| Bishop Pablo Varela | USMA |
| Name | Organization |
| Honorable Diputada Yanibel Abrego de García | Asamblea Nacional |
| Dr. Eloy Alfaro | |
| Dra. Angela Arrue | |
| Dr. Eldredge Bermingham | Smithsonian Tropical Research Institute |
| Dra. Georgina de Alba | Smithsonian Tropical Research Institute |
| Dr. Juan Bosco Bernal | |
| Dr. Rubén Berrocal | SENACYT |
| Sr. Elberto Cobos | |
| Dr. Julio Escobar | |
| Lic. Gabriel Galindo | |
| Dr. Gustavo García de Paredes | Universidad de Panamá |
| Sr. Luis González | |
| Lic. Fernando Manfredo | |
| Su Excelencia Lucy Molinar | Ministra de Educación |
| Dr. Juan David Morgan | |
| Lic. Stanley Motta | |
| Su Excelencia Demetrio Papadimitriu | Ministro de la Presidencia |
| Ing. Marcela Paredes de Vásquez | Universidad Tecnológica |
| Ing. Roberto Roy | |
| Ing. Modaldo Tuñón | Universidad Latina |
| Ing. Modaldo Tuñón | Consejo de Rectores |
| Su Excelencia Alberto Vallarino | Ministro de Economía y Finanzas |
| Ing. Guillermo Van Hoorde | |
| Su Excelencia Juan Carlos Varela | Ministro de Relaciones Exteriores |
| Mons. Pablo Varela | USMA |